Background

The recently validated Lupus Low Disease Activity State (LLDAS) definition has been shown to have utility as a treat to target endpoint in SLE, whereby LLDAS attainment is associated with reduction in permanent damage accrual. Robust evaluation is required to ensure this protective association is not simply reflective of milder disease phenotypes being over-represented among LLDAS attainers.

Objectives

To assess the effect of attainment of LLDAS on damage accrual in patients with active disease at baseline. SLEDAI-2K≥6 was chosen as this reflects clinical trial entry criteria.

Methods

A prospective multinational cohort study was undertaken in 13 centres between 2013-2017. Patients with SLE were recruited, SLEDAI-2k, SELENA flare index, PGA, and medication data collected at every visit, and damage score (SLICC-ACR damage index (SDI)) collected annually. Subgroup analyses were …

Identitas Publikasi Ilmiah

Tanggal Publikasi 01 Juni 2019
Edisi Suppl 2
Volume 78
Halaman 203
Tahun 2019
Status publikasi
Relasi Project Penelitian
Staf Pendukung Publikasi Ilmiah
Nama Sebagai

Dokumen Publikasi Ilmiah

Tidak Terdapat Dokumen Untuk Publikasi Ilmiah OP0246 ATTAINMENT OF THE LUPUS LOW DISEASE ACTIVITY STATE IS ASSOCIATED WITH PROTECTION FROM DAMAGE ACCRUAL IN PATIENTS WITH ACTIVE DISEASE AT BASELINE