Early clearance (EC) is the successful eradication of inhaled Mycobacterium tuberculosis before an adaptive immune response develops. Evidence for EC comes from case contact studies that consistently show that a proportion of heavily exposed individuals do not develop M. tuberculosis infection. Further support for the existence of this phenotype comes from genetic loci associated with tuberculin reactivity. In this review we discuss aspects of the innate response that may underpin EC and hypotheses that can be tested through field laboratory link studies in M. tuberculosis case contacts. Specifically, we consider mechanisms whereby alveolar macrophages recognize and kill intracellular M. tuberculosis, and how other cell types, such as neutrophils, natural killer T cells, mucosa-associated invariant T cells and cd T cells may assist. How EC may be impaired by HIV infection or vitamin D deficiency is also explored. As EC is a form of protective immunity, further study may advance the development of vaccines and immunotherapies to prevent M. tuberculosis infection.

Identitas Publikasi Ilmiah

Tanggal Publikasi 01 April 2014
Edisi Immunology
Volume 4
Halaman 141
Tahun 2014
Status publikasi
Relasi Project Penelitian TANDEM (Concurrent Tuberculosis and Diabetes Mellitus; Unravelling the causal link, and improving care
Staf Pendukung Publikasi Ilmiah
Nama Sebagai

Dokumen Publikasi Ilmiah

Tidak Terdapat Dokumen Untuk Publikasi Ilmiah Early clearance of Mycobacterium tuberculosis: a new frontier in prevention.