Background: As in other developing countries, cervical cancer is the most frequent gynecologic malignancy in
Indonesia. Persistent high risk genotypes of human papillomavirus (HPV) that infect the cervical tissue have been
established as the etiology of cervical cancer. This study aimed to explore the profile of cervical cancer patients and
the infected HPV genotypes at Dr. Hasan Sadikin General Hospital-Bandung. Materials and Methods: During the
year 2010, 554 cervical cancer patients were registered. In a subset of the patients during July – November 2010,
40 randomized fresh biopsies were tested for HPV genotype after obtained informed consent. The distribution
of HPV genotypes and the association to risk factors were analysed. Results: The result showed that 62.5% of
the tested biopsies were infected by multiple HPV infections, with HPV-16 found in most of the cervical cancer
patients (90%). Marriage at age younger than 16 years old was statistically significant in relation to multiple
HPV infection (p=0.003), but not parity more than three times (p=0.59). Conclusions: Although high paritiy in
our study was not associated with multiple HPV infection, good family planning programs and reproductive
health education need to be emphasized in Indonesia as high parity and marriage at young age might increase
the chance of cervical cancer development.
Keywords: Bandung - cervical cancer - HPV - multiple HPV infections - high parity - young marriage

Identitas Publikasi Ilmiah

Tanggal Publikasi 01 Desember 2014
Edisi Asian Pac J Cancer Prev, 15
Volume 14
Halaman 5781
Tahun 2014
Status publikasi
Relasi Project Penelitian
Staf Pendukung Publikasi Ilmiah
Nama Sebagai

Dokumen Publikasi Ilmiah

Tidak Terdapat Dokumen Untuk Publikasi Ilmiah Human Papillomavirus Genotypes Profile in Cervical Cancer Patients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia Maringan Diapari Lumban Tobing1,3, Edhyana Sahiratmadja2,3, Mufti Dinda3, Bethy Suryawathy Hernowo4, Herman Susanto1,3*